Peptidylglycine alpha-amidating monooxygenase antibody drug, batch concentration finder
Anti-PAM antibody (ab77592)
PAM mRNA levels were found to be 3-fold higher in prostate adenocarcinomas compared with that of human benign prostate hyperplasia BPH as demonstrated by real-time quantitative reverse transcription-PCR .
The multifunctional peptidylglycine alpha-amidating monooxygenase gene: There have been significant advances in the understanding of the dioxygen -activation chemistry of mononuclear copper monooxygenases such as peptidylglycine alpha-amidating monooxygenase and dopamine beta-monooxygenase DbetaM .
The first step of the reaction is catalysed by peptidylglycine alpha-hydroxylating monooxygenase PHMand is dependent on copper, ascorbate and molecular oxygen; peptidyl-alpha-hydroxyglycine alpha-amidating lyase PAL catalyses the second step of the reaction [ PMID: Levels of alpha-amidating activity, peptidyl-glycine alpha-amidating monooxygenase PAMwere hypertracker free alternative dating in the CSF of patients with dementia of the Alzheimer type DAT compared with healthy, age-matched controls .
Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase . PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila.
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Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation. Blood acid-base status, serum electrolytes, and urine pH were examined in 64 infants and children with phenylketonuria PKU treated with three different low phenylalanine protein hydrolyzates Aponti, Cymogran, AlbumaidXP and two synthetic amino acid mixtures Aminogran, PAM .
The protein contains two enzymes, peptidylglycine alpha-hydroxylating monooxygenase PHM and peptidyl-alpha-hydroxyglycine alpha-amidating lyase PALthat act sequentially to catalyse the alpha-amidation of neuroendocrine peptides [ PMID: Although some of the truncated PAM protein was also processed and stored in AtT cells, much of the expressed protein was redistributed to the plasma membrane .
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The optimal pH for amidating activity was 5. A comparison of PAM activity and DDC levels in 30 lung cancer cell lines indicated that peptide amidating activity may be an indicator of NE status .
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